(INDIANAPOLIS) – The Indianapolis Colts keep insisting Jacoby Brissett could win games with his arm. On Sunday, he showed everyone else what the team knew all along. With Indy's suddenly strong running game essentially grounded, Brissett shouldered the burden by throwing for 326 yards and a career-high four touchdowns to lead the Colts past Houston 30-23 to retake the AFC South lead. Brissett finished 26 of 39 with six of the incompletions being throwaways. He had a career best passing total, a career best passer rating (126.7), endured only one sack and had the perfect counterpunch each time Houston fought its way back into contention. The Colts (4-2) have now won two straight overall and three straight in the series. And it only added to the Texans' misery. They were held to field goals on three red-zone trips in the first half, had to contend with a rare "in the grasp" call that took one touchdown off the board, an overturned replay review that put another one on the board for Indy and a plethora of penalties that Brissett used to his advantage. Houston (4-3) was called for 10 penalties. Zach Pascal had 6 receptions for 106 yards for the Colts while T.Y. Hilton had 6 grabs for 74 yards. Deshaun Watson was 23 of 34 with 308 yards, one touchdown and was sacked three times as the Texans tried to play catch-up against the Colts.