(INDIANAPOLIS) – The Indianapolis Colts finally got their offense running again Sunday. Marlon Mack waited patiently for holes to open. Jonathan Williams took advantage of each opportunity. Jacoby Brissett and Nyheim Hines both ran for scores, and even All-Pro left guard Quenton Nelson got a chance to carry the ball. The throwback strategy worked perfectly. Indy rushed for a season-high 264 yards and overpowered Jacksonville 33-13 for the franchise's 300th win since moving to Indianapolis in 1984. The Colts turned a milestone day into an unforgettable performance. Mack ran 14 times for 109 yards and one score before leaving in the third quarter with a hand injury. Williams finished with 13 carries for a career-high 109 yards and twice gave himself up after long, fourth-quarter runs to keep the clock moving. It's the first time the Colts have had two 100 yard runners in a game since Oct. 6, 1985, and only the third time in franchise history. Indy (6-4), meanwhile, snapped a two-game losing streak and reclaimed a share of the AFC South when Houston lost to Baltimore. Brissett went 15 of 24 with 148 yards, one touchdown and one interception after missing last week's game with a bad left knee. Nick Foles was 33 of 47 with 296 yards, two touchdowns and one interception as the Jaguars (4-6) in his first game back.